Neuroscience EMAPublication Library
All publications
Article#webpage

Botox for Chronic Migraine: What Patients Should Know

Botox is FDA-approved specifically for chronic migraine in adults with 15+ headache days per month

22 Aug 2026 1 min read

Botox (onabotulinumtoxinA) is an FDA-approved treatment specifically for chronic migraine in adults who experience 15 or more headache days per month, with at least 8 of those being migraine days. This prescription medication works differently from oral migraine treatments by targeting nerve pathways involved in chronic migraine pain.

The treatment involves injections administered by a healthcare provider every 12 weeks across specific areas of the head and neck. Clinical studies have shown that Botox can reduce the number of headache days per month for people with chronic migraine. The treatment typically involves 31 injections using a very fine needle, and the procedure usually takes about 15 minutes.

Patients should discuss their complete medical history with their healthcare provider before starting Botox treatment, including any medications they're taking and previous treatments they've tried. Common side effects may include neck pain, headache, and injection site reactions. Some patients may begin to see improvement within 2-3 weeks after their first treatment, though it may take multiple treatment cycles to experience the full benefit.

Botox for chronic migraine is different from cosmetic Botox treatments and requires specific training for proper administration. Patients should only receive treatment from qualified healthcare providers experienced in migraine management and Botox injection techniques.

Related publications